Endocrine Abstracts

Introduction: The prevalence of vitamin D deficiency is high, and yet still little recognized and treated. Cardiovascular diseases are the leading causes of morbidity and mortality worldwide and the emergence of evidence with the link suggesting an association between vitamin D deficiency and cardiovascular risk (CVR), it is pertinent to better understand this association.Objective: This study aimed to relate the levels of 25 (OH) D in obese patients wit...

Introduction: Pheochromocytomas are tumors derived from the adrenal-medullary chromaffin cells that normally produce catecholamines. Rarely these tumors are non-secreting. In the assessment of a suspected pheochromocytoma, guidelines recommend dosing urinary or plasma metanephrines.Objective: To evaluate the prevalence of pheochromocytomas biochemically non-secreting and their differences.Methods: We searched all patients with meas...

Introduction: The association of hyperthyroidism and thyroid cancer (TC) is controversial with prevalences in the literature varying from 1.6 to 32.8%. The aim of this work was to evaluate the prevalence of TC in hyperthyroid patients submitted to surgery and to find differences between the tumors according to the type of hyperthyroidism.Material and methods: retrospective study to evaluate clinical and histopathological data of all hyperthyroid patients...

Several studies have shown a link between pro-inflammatory activity and the presence or relative deficit of some fatty acids. A low amount of omega 3 fatty acids, appears to promote an inflammatory profile. The omega 6 fatty acids have also the same effect. It is well known that a chronic low-grade inflammation is associated to several diseases, namely, diabetes. The follow-up of children and young people with Type 1 diabetes involves the periodic evaluation of their lipidic p...

Introduction: ‘PreDiabetes’ was considered as a categories of increased risk for diabetes on the last ADA recommendations in 2010. The proposed diagnostic criteria include an HbA1c value between 5.7 and 6.4%, impaired fasting glucose (IFG) (100–125 mg/dl) and impaired glucose tolerance (IGT) levels (2-h values in the oral glucose tolerance test (OGTT) of 140 to 199 mg/dl). The HbA1c as new diagnostic criteria may actually increase the number of patients diagnose...

Infertility is a growing concern in Western countries. Several factors, including lifestyle habits and increased prevalence of chronic disorders associated with hormonal alterations, increased chronic inflammation and systemic oxidative stress (such as obesity and diabetes mellitus), are contributing to the reduction of reproductive potential among males in modern societies. Evidence suggests these factors negatively impact human sperm quality resulting in a combination of alt...

Introduction: The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid follicular cells, enabling the use of radioactive iodine (RAI) for treatment of metastatic disease. Still, a significant proportion of patients with advanced forms of thyroid cancer (TC) became refractory to RAI therapy. Defective NIS expression is the main reason for impaired iodide uptake in TC and NIS downregulation has been associated with several pathways linked to m...

Introduction: Type 1 diabetes (T1D) is an important endocrine disease in the pediatric age group. The shift from pediatrics to adult health care providers is a critical period for adolescents with diabetes.Objective: Characterization of a pediatric population with T1D moved to adult health care between January/2001–April/2015.Methods: Cross-sectional study with retrospective analysis of medical records.R...

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic disease, with prevalence increasing worldwide and its complications are major causes of early morbidity and mortality. Recent guidelines suggest the individualisation of glycaemic targets and glucose-lowering therapies.The aim of this study was to determine the quality of care provided to type 2 diabetic patients in our institution, analysing metabolic control, cardiovascular risk factors and pre...

Introduction: Moderate weight loss (5–10%) translates into health benefits, including improvement in cardiovascular risk. It is essential to assess the results and indicators of success in treating obesity, which is the objective of this work.Methods: A retrospective study of patients with overweight and obesity, followed in Nutrition consultation between 2004 and 2010. We analyzed biodemographic and anthropometric variables, consultation reason and...